Selenoprotein O is a protein that in humans is encoded by the SELENOO gene. [5]

Function

This gene encodes a selenoprotein, pseudokinase selenoprotein-O(SelO), that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The SELO protein AMPylates proteins involved in redox homeostasis. As a result this selenoprotein is thought to be necessary for the cellular response to oxidative stress. [6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073169 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035757 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Selenoprotein O". Retrieved 2018-05-18.
  6. ^ Sreelatha A (October 18, 2018). "Protein AMPylation by an Evolutionarily Conserved Pseudokinase". Cell. 175 (3): 809–821.e19. doi:10.1016/j.cell.2018.08.046. PMC 6524645. PMID 30270044.

Further reading

  • Mabuchi H, Tatami R, Ueda K, Ueda R, Haba T, Kametani T, Watanabe A, Wakasugi T, Ito S, Koizumi J, Ohta M, Miyamoto S, Takeda R (April 1979). "Serum lipid and lipoprotein levels in Japanese patients with familial hypercholesterolemia". Atherosclerosis. 32 (4): 435–44. doi:10.1016/0021-9150(79)90009-1. PMID 223596.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Allikas: https://en.wikipedia.org/wiki/Selenoprotein_O
No tags for this post.