SSB may refer to:

• Scandinavian School of Brussels
• Social Security Board (disambiguation)
• Societas Sanctae Birgittae, the Society of Saint Bridget
• Society of the Sisters of Bethany, an Anglican order of sisters
• Society of Systematic Biologists
• Städtische Strassenbahn Bern, a former public transport operator in Switzerland
• Statistics Norway (Norwegian: Statistisk sentralbyrå), a Norwegian government statistics bureau
• Stuttgarter Straßenbahnen, a public transport operator in Germany
• Sustainable South Bronx, an environmental justice organization
• Swedish School Beijing, a former international school in China (1994–2015)
• Smoke Signal Broadcasting, a defunct American computer company

• Presidency of Defense Industries (Turkish: Savunma Sanayii Başkanlığı) of Turkey
• SSB (militia), paramilitary clan militia that operates in the Sool, Sanaag and Togdheer regions of Somaliland
• Sashastra Seema Bal, Indian border patrol force, formerly called Special Service Bureau
• Secret Service Bureau, of the United Kingdom, now called the Secret Intelligence Service
• Services Selection Board, for the selection of candidates in officer cadre of Indian Armed Forces
• Special Service Battalion, a South African military unit
• Strategic Support Branch, a U.S. Department of Defense intelligence agency

• Secure Scuttlebutt
• Single-sideband modulation, in radio technology
• Single-stranded binding protein
• Single-strand break, a break in only one of the two strands on DNA
• Site-specific browser, for an intranet or the Internet
• Sjögren syndrome antigen B, a human gene
• Speculative Store Bypass, a hardware security flaw affecting many processors
• Spontaneous symmetry breaking, in physics
• Stabilized soil block, a type of compressed earth block, a building material
• Solid-state battery, an electrical battery that uses a solid electrolyte

• Sonic Soldier Borgman, a Japanese animated television series
• Super Smash Bros., a platform fighting game series featuring characters from Nintendo and third-party franchises
  • Super Smash Bros. (video game), the first game in the series
• Swet Shop Boys, a hip hop group

• Ship Submersible Ballistic, a submarine
• Standard Southern British, a name for a variety of English
• Sugar-Sweetened Beverage, a formal term for soda