Port Phillip is a large bay in southern Victoria, Australia. It is named after British colonial administrator Arthur Phillip and adjoins the city of Melbourne.

It may also locally refer to

• City of Port Phillip, local government area in Melbourne
• Port Phillip Association, company formed in June 1835 to settle land in what would become Melbourne
• Port Phillip Bay (Western Shoreline) and Bellarine Peninsula Ramsar Site
• Port Phillip Channel Deepening Project
• Port Phillip District, historical administrative division of the Colony of New South Wales, later to become the core of the state of Victoria
• Port Phillip District Special Surveys, part of land settlement legislation in 1841
• Port Phillip Gazette, Melbourne newspaper 1838-1851
• Port Phillip Heads Marine National Park
• Port Phillip Herald, Melbourne newspaper est. 1840
• Port Phillip Prison, Truganina, Victoria
• Port Phillip Protectorate, 1839 attempt to protect Aborigines
• Port Phillip Arcade, Melbourne, a shopping arcade in the city of Melbourne

• Port Philip, Nova Scotia