Pfennig (also Pfenning or Pfenninger) is a German surname. Notable people with the surname include:
- Frank Pfenning, professor of computer science
- Fritz Pfenninger
- Norbert Pfennig (1925–2008), German microbiologist
- Jörn Pfennig (born 1944), German jazz musician, lyricist
- Oscar Pfennig (1880–1963), German architect
- Werner Pfennig (1937–2008), German trade unionist
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