Osborne may refer to:

• Osborne (name)

• Osborne, South Australia (disambiguation), places associated with the suburb in the Adelaide metropolitan area
• Osborne, New South Wales, a rural community in the Riverina region

• Osborne (Manitoba riding), a former provincial electoral district
• Osborne, Lambton County, Ontario
• Osborne, Manitoba, a hamlet
• Osborne Township, Ontario
• Osborne Village, a neighbourhood in Winnipeg, Manitoba

• Osborne Bay, Isle of Wight

• Osborne, Kansas, a city
• Osborne, Pennsylvania, a borough, renamed Glen Osborne
• Osborne County, Kansas
• Osborne Township, Pipestone County, Minnesota

• Osborne (computer retailer), an Australian computer retailer
• Osborne Computer Corporation, computer company created by Adam Osborne
  • Osborne 1 portable computer
• Osborne Group, Spanish producer of spirits and meats

• The Osborne, a historic apartment building in Manhattan, New York, United States
• Osborne Association, a New York-based criminal justice reform and direct service organization
• Osborne bull, the unofficial national emblem of Spain
• Osborne effect, a marketing myth
• HMY Osborne (1870), a royal yacht of the United Kingdom
• USS Osborne (DD-295), a Clemson-class destroyer in the United States Navy

• Osborn (disambiguation)
• Osbourne (disambiguation)
• Osborne House (disambiguation)
• Osborne Park (disambiguation)
• Usborne (disambiguation)