Issue 1 may refer to:

• 2012 Arkansas Issue 1, a successful ballot measure to raise sales tax to pay for highway improvements

• 2004 Ohio Issue 1, a successful ballot measure banning same-sex marriage in the state
• May 2018 Ohio Issue 1, a successful ballot measure regarding congressional redistricting
• 2022 Ohio Issue 1, a successful ballot measure regarding cash bail procedures
• August 2023 Ohio Issue 1, a failed ballot measure regarding the process for proposing and approving amendments to the Ohio state constitution
• November 2023 Ohio Issue 1, a successful ballot measure codifying abortion rights in the state constitution.
• 2024 Ohio Issue 1, a redistricting commission initiative

• Issue One, an American non-profit organization that seeks to reduce the role of money in politics

• First issue
• Proposition 1