Nicholas or Nick Harrison may refer to:

• Nicholas Harrison (physicist) (born 1964), English theoretical physicist
• Nicholas Harrison (athlete) (born 1970), Australian long-distance runner
• Nick Harrison (cricketer) (born 1992), English cricketer
• Nick Harrison (racing) (1982–2019), American stock car racing crew chief
• Nick Harrison (Shortland Street), a character on Shortland Street
• Nicky Harrison, strings arranger for The Rolling Stones' album Goats Head Soup