Neopluramycin is an antibiotic that inhibits nucleic acid synthesis. It has been isolated from the cultured broth of a strain of Streptomyces pluricolorescens as orange crystals, and analytical data and molecular weight determination are consistent with the empirical formula C
41H
50N
2O
10.[1]

Neopluramycin resembles pluramycin A, but is differentiated by its antibacterial spectrum, toxicity, thin-layer chromatography, and infrared absorption spectrum.[1]

Neopluramycin inhibits growth of Gram-positive bacteria, leukemia L-1210 in mice and Yoshida rat sarcoma cells in tissue culture.[1][2]

References

  1. ^ a b c Kondo S, Wakashiro T, Hamada M, Maeda K, Takeuchi T (July 1970). "Isolation and characterization of a new antibiotic, neopluramycin". The Journal of Antibiotics. 23 (7): 354–9. doi:10.7164/antibiotics.23.354. PMID 5460277.
  2. ^ Tsukada I, Hamada M, Umezawa H, Hori M, Hayashi H (March 1971). "Neopluramycin, an inhibitor of nucleic acid synthesis". The Journal of Antibiotics. 24 (3): 189–96. doi:10.7164/antibiotics.24.189. PMID 4323924.


Allikas: https://en.wikipedia.org/wiki/Neopluramycin
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