Moshe Shmuel Shapiro (1917–2006) was a rosh yeshiva (dean of a Jewish seminary).

Shapiro was born in the Minsk, Belarus. In 1937 he moved to Palestine.

In Israel, Shapiro attended Yeshivas Lomza in Petah Tikva and was granted semikhah (ordained as a rabbi). He married in 1946.

• Kuntres Ha-Biurim, an in-depth analysis of various Talmudic topics.

• Sha'arei Shemu'os , a compilation of Shapiro's novellae arranged by folio of the Talmudic tractates on which he commented.

• British Jewry Anticipates Visit Of Harav Moshe Shmuel Shapira
• HaRav Moshe Shmuel Shapira zt'l

• Biography of Rabbi Moshe Shmuel Shapira