Muhammad Omar (Arabic: محمد عمر), and other spellings such as Mohamed Omer, may refer to the following people:

• Muhammad Umar (wrestler) (born 1975), Pakistani wrestler
• Mohammad Omar (footballer, born 1976), Emirati footballer
• Mohammed Omar (footballer, born 1983), Qatari footballer
• Muhammad Omar (footballer, born 1990), Pakistani footballer
• Mohamed Omar (soccer, born 1999), Canadian soccer player

• Mohamed Salih Omer (1934–1969), Sudanese politician
• Mohammad Iqbal Omar (born 1972), Iraqi politician
• Mohammad Omar (Afghan governor) (died 2010), Governor of Kunduz Province, Afghanistan
• Mullah Omar (died 2013), founder and former leader of the Taliban
• Mohamed Omer (Eritrean politician), interim foreign minister of Eritrea
• Mohammad Abdullahi Omar, Somali politician
• Mohammad Farid Omar, Afghan Taliban politician
• Muhammad Zubair Umar, Pakistani politician

• Mohammad Omar (musician) (1905–1980), Afghan musician and Rubab virtuoso
• Mohamed Omar (born 1976), Swedish poet who changed his name to Eddie Råbock in 2017
• Mohammed Omer (journalist) (born 1984), Palestinian journalist
• Mohamed Omar (mathematician), Egyptian-Canadian mathematician working in the United States

• Muhammad Umar Memon (1939–2008), Pakistani literary scholar
• Mohammad Omar Daudzai (born 1957), Afghan politician
• Muhammad Umar Memon (born 1958), Egyptian footballer
• Mohamed Omar Hagi Mohamoud (born 1981), Somali diplomat
• Mohammad Omar Shishani (born 1989), Jordanian footballer
• Mohammed Omar Abdel-Rahman, Egyptian extrajudicial prisoner of the US
• Mohamed Omar Arte, Somali politician
• Omar Mohamed Omar (1970–2008), Somali basketball player
• Amin Omar (born 1985), Egyptian football referee
• Daud Mohamed Omar, Somali politician