Michael Frank (1804–1894) was an American pioneer, newspaper editor, and politician.
Michael Frank may also refer to:
- Michael Frank (music producer), the founder of the Earwig Music Company
- Michael Sigismund Frank (1770–1847), Catholic artist and rediscoverer of the lost art of glass-painting
- Michael C. Frank, developmental psychologist at Stanford University
- Michael J. Frank, neuroscientist
- Mike Frank, American Major League Baseball outfielder
- Michael Frank (film director), Australian film director
- Michael Frank, creator of the Museum of Bad Art
- Michael Frank (writer), American writer
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