McDonough (McDonogh) is an Irish surname.

McDonough, McDonogh may also refer to:

• McDonough, Delaware
• McDonough, Georgia
• McDonogh, Louisiana
• McDonough, New York
• McDonough County, Illinois
• MacDonough Island, Island County, Washington
• McDonogh Place Historic District, Baltimore, Maryland
• Lake McDonough, Barkhamsted, Connecticut

• McDonogh No. 35 Senior High School, New Orleans, Louisiana
• McDonogh 19 Elementary School, New Orleans, Louisiana
• John McDonogh High School, New Orleans, Louisiana
• McDonogh School, a college-preparatory school in Owings Mills, Maryland
• Maurice J. McDonough High School, Charles County, Maryland
• McDonough School of Business, Georgetown University, Washington, D.C.
• Alma Grace McDonough Health and Recreation Center, Wheeling Jesuit University in Wheeling, West Virginia

• USS Macdonough (DD-9), an early destroyer that served from 1900 to 1919
• USS Macdonough (DD-331), a Clemson-class destroyer that served from 1920 to 1930
• USS Macdonough (DD-351), a Farragut-class destroyer that served from 1934 to 1945
• USS Macdonough (DDG-39), a Farragut-class guided missile frigate (destroyer leader) that served from 1959 to 1992
• USS Commodore McDonough, an 1862 ferryboat acquired by the Union Navy for use as a gunboat during the American Civil War

• McDonough County Courthouse, in Macomb, Illinois
• McDonough Gymnasium, a multi-purpose arena in Washington, D.C.
• McDonough Museum of Art, in Youngstown, Ohio
• McDonough Park, a stadium in Geneva, New York
• McDonogh Road, in Baltimore County, Maryland
• McDonough–Fayetteville Road, part of Georgia State Route 920 in Metro Atlanta area, Georgia
• McDonough syndrome, medical condition

• All pages with titles containing MacDonough
• All pages with titles containing McDonough
• All pages with titles containing McDonogh