Mark Smith may refer to:

• Marc Smith (palaeographer) (born 1963), French palaeographer
• Mark Smith (physicist), British physicist and Vice-Chancellor of Lancaster University
• Mark A. Smith (1965–2010), professor of pathology at Case Western Reserve University
• Mark M. Smith (active since 1997), American historian
• Mark S. Smith (born 1956), American biblical scholar, professor at NYU

• Mark Smith (actor, born 1887) (1887–1944), American actor
• Mark Smith (actor, born 1969) (born 1969), English bodybuilder and participant on the UK television show Gladiators
• Mark Smith (sound engineer) (active since 1987), American sound engineer who won an Academy Award
• Mark Coles Smith (born 1987), Australian actor
• Mark L. Smith (born 1996), American director and screenwriter
• Mark Landon Smith (born 1964), American playwright and actor

• Mark Smith (author), British author of fantasy game books
• Mark Smith (journalist), American journalist
• Mark Smith (novelist) (born 1935), American best-selling author
• Mark Andrew Smith (born 1979), American comic book author
• Mark Haskell Smith (born 1957), American writer

• Mark Smith, member of post-rock band Explosions in the Sky (active since 1999)
• Mark Smith (musician) (1960–2009), British bassist and record producer
• Mark E. Smith (1957–2018), British singer and founder of The Fall
• Mark Edgley Smith (1955–2008), British composer

• Mark T. Smith (born 1968), American painter

• Mark Smith (Iowa politician) (born 1952), American state representative
• Mark Smith (South Carolina politician), American state representative-elect
• Mark Smith (Canadian politician) (born 1960), Canadian politician for the Legislative Assembly of Alberta
• Mark W. Smith (born 1968), American author, attorney, and political analyst
• Marcus A. Smith (1851–1924), known as Mark, U.S. Senator from Arizona

• Mark L. Smith (physician) (active since 1999), American physician and plastic surgeon
• Mark Smith (R/C modeling pioneer) (born 1950), designer of radio-controlled model airplanes

• Mark Smith (American football) (born 1974), American football player
• Mark Smith (American racing driver) (born 1967), American CART competitor
• Mark Smith (athlete) (born 1971), English athlete
• Mark Smith (basketball) (born 1999), American basketball player
• Mark Smith (British racing driver) (born 1965), English BTCC competitor
• Mark Smith (cricketer) (born 1975), Zimbabwean cricketer
• Mark Smith (fencer) (born 1956), American Olympic fencer
• Mark Smith (footballer, born 1960), English football player (Sheffield Wednesday)
• Mark Smith (footballer, born October 1961), English football player (West Ham United)
• Mark Smith (footballer, born December 1961), English football player and manager
• Mark Smith (footballer, born 1964), Scottish football player (Stoke City)
• Mark Smith (footballer, born 1973), English football player (Crewe Alexandra)
• Mark Smith (ice hockey) (born 1977), Canadian professional ice hockey player
• Mark Smith (outfielder) (born 1970), American former professional baseball player
• Mark Smith (Pennsylvanian racing driver) (born 1971), racing driver from Pennsylvania
• Mark Smith (pitcher) (born 1955), American former professional baseball player
• Mark Smith (racing engineer) (born 1961), Formula One designer
• Mark Smith (rugby league) (born 1981), English former rugby league player
• Bison Smith (Mark Smith, 1973–2011), American professional wrestler
• Mark Smith (high jumper), winner of the 1953 NCAA DI outdoor high jump championship

• Mark C. Smith (1940–2007), founder and chief executive officer of ADTRAN
• Mark E. Smith (Civil Air Patrol), National Commander of the Civil Air Patrol
• Mark Alan Smith (born 1949), American serial killer
• Mark Smith, creator of the train travel website The Man in Seat Sixty-One

• Marc Smith (disambiguation)
• Marcus Smith (disambiguation)
• Mark Durden-Smith (born 1968), British television presenter