Mark Green or Greene may refer to:

• Mark Green (American football) (born 1967), NFL running back
• Mark Green (ice hockey) (1967–2004), American professional ice hockey player
• Mark Green (racing driver) (born 1959), veteran driver in the NASCAR Busch Series
• Mark Greene (footballer) (born 1959), Australian rules footballer

• Mark Green (New York politician) (born 1945), lawyer and New York City Public Advocate
• Mark Green (Wisconsin politician) (born 1960), member of the United States House of Representatives from Wisconsin
• Mark Green (Tennessee politician) (born 1964), member of the United States House of Representatives from Tennessee

• Mark Green (bishop) (1917–2009), bishop of Aston
• Mark A. Greene, American archivist, director of American Heritage Center
• Mark F. Green (born 1953), American lawyer from Oklahoma
• Mark I. Greene, professor of pathology
• Mark Lee Green (born 1947), American mathematician
• Mark M. Green (born 1937), professor of Chemistry at NYU
• Mark N. Greene, CEO of OpenLink

• Mark Greene, fictional character on the television series ER

• Mark Greenaway
• Mark Greenblatt
• Mark Greenstreet
• Mark Greenwald
• Mark Greenwold