Mac Domangairt is a Scottish surname. Notable people with the surname include:
- Comgall mac Domangairt (6th century), king of Dál Riata
- Eochaid mac Domangairt (died ca. 697), king of Dál Riata (modern western Scotland)
- Gabrán mac Domangairt (6th century), king of Dál Riata
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