Lobo, in comics, may refer to:

• Lobo (DC Comics), the alien bounty hunter
• Lobo (Dell Comics), the African-American comic book character
• Lobo the Duck, an Amalgam Comics fusion of DC's Lobo and Marvel's Howard the Duck

It may also refer to:

• Lobo Brothers, two Marvel Comics werewolves
• Maximus Lobo, a Marvel Comics character

• Lobo (disambiguation)