José Lopez may refer to:

• José López (infielder) (born 1983), Venezuelan baseball player
• José López (outfielder) (1901–?), Cuban baseball player
• José López (pitcher) (born 1999), Dominican baseball player

• José Toluco López (1932–1972), Mexican lightweight boxer
• José López (boxer) (born 1972), Puerto Rican boxer
• José Luis López (boxer) (born 1973), Mexican welterweight boxer
• José Eduardo López (born 1990), Mexican light welterweight boxer

• José López (cyclist) (born 1910), Argentine cyclist
• José Manuel López Rodríguez (born 1940), Spanish cyclist
• José Antonio López (born 1976), Spanish cyclist

• José López (footballer, born 1914), Spanish footballer
• Juan José López (born 1950), Argentine football manager and former player
• José López Ramírez (born 1975), Spanish 5-a-side football player
• José Luis López (Mexican footballer) (born 1979), Mexican footballer
• José Manuel López (footballer) (born 2000), Argentine footballer
• José Alfredo López, Argentine footballer
• José López (Chilean footballer)

• José López (wrestler) (born 1930), Cuban Olympic wrestler
• José Perurena López (born 1945), Spanish sprint canoer
• José Ramón López (born 1950), Spanish sprint canoer
• José López (athlete) (born 1967), Venezuelan runner
• José María López (born 1983), Argentine race-car driver
• José Luis López (handballer) (born 1998), Chilean handball player

• José Hilario López (1798–1869), Colombian president and military officer
• José López Portillo y Rojas (1850–1923), Mexican writer and politician
• José López Rega (1916–1989), Argentine politician
• José López Portillo y Pacheco (1920–2004), Mexican president
• José Francisco López, Argentine politician detained pending trial

• José López Rubio (1903–1996), Spanish writer and director
• José Luis López Vázquez (1922–2009), Spanish actor
• José Serafín López (died 1935), Chilean politician
• José "Nuno" López (born 1951), Puerto Rican politician

• José Antonio López (1781–1841), Spanish Mexican Jesuit
• José M. López (1910–2005), American soldier
• José Salazar López (1910–1991), Mexican cardinal
• José Venancio López (1791–1863), Guatemalan jurist and politician
• José M. López (judge), District of Columbia judge
• Jose V. Lopez, American-Filipino Molecular Biologist