John Cooke may refer to:

• John R. Cooke (1788–1854), Virginia planter, lawyer and politician
• John Robert Cooke (1866–1934), political figure in Ontario
• John Herbert Cooke (1867–1943), Australian politician
• John B. Cooke (1885–1971), served in the California legislature
• John H. Cooke (1911–1998), New York politician and judge
• John Warren Cooke (1915–2009), American politician from Virginia
• John William Cooke (1919–1968), Argentine politician and revolutionary
• John Cooke (Colorado politician) (fl. 2000s–2020s)

• John Cooke (Oxford University cricketer) (1808–1841), English cricketer
• John Cooke (Derbyshire cricketer) (1851–1908), English cricketer
• John Cooke (footballer, born 1878), English professional footballer
• John Cooke (rower) (1937–2005), American rower at the 1956 Olympics
• John Cooke (sport shooter) (1939–2008), British sport shooter
• John Cooke (footballer, born 1942), English professional footballer
• John Cooke (footballer, born 1962), English professional footballer

• John Cooke (composer), English composer with works in the Old Hall Manuscript
• John Cooke (fl. c. 1611), author of the play Greene's Tu Quoque
• John Cook (regicide) (1608–1660), English Solicitor General, prosecuted King Charles I
• John Cook (pirate) or John Cooke (died 1684), English pirate, associate of Edward Davis
• John J. Cooke (1874–1921), American actor of silent era
• John Cooke (Six Preacher) (1646/7–1726), Anglican clergyman
• John Cooke (judge) (1944–2022), Irish judge
• John Cooke (lawyer) (1666–1710), English lawyer
• John Cooke (academic) (1734–1823), Vice-Chancellor of Oxford University
• John Cooke (physician) (1756–1838), British physician, Fellow of the Royal Society and of the Society of Antiquaries of London
• John Cooke (Royal Navy officer) (1763–1805), British captain killed at the Battle of Trafalgar
• John Cooke (entrepreneur) (1824–1882), American locomotive maker
• John Esten Cooke (1830–1886), American novelist, Confederate Army officer
• John Peyton Cooke, American novelist
• John Rogers Cooke (1833–1891), Confederate general during the American Civil War
• John Starr Cooke (1920–1976), American mystic and spiritual teacher
• John Cooke (RAF officer) (1922–2011), British doctor and senior Royal Air Force officer
• John Byrne Cooke (1940–2017), American author, musician and photographer
• John Cooke (musician), English guitarist

• John Cook (disambiguation)
• John Coke (disambiguation) (pronounced Cook)