John Clark House may refer to:

• Capt. John Clark House, Canterbury, Connecticut, listed on the National Register of Historic Places (NRHP)
• John Clark House (Lexington, Kentucky), listed on the NRHP in Fayette County, Kentucky
• John Clark House (Rockville, Minnesota), part of an NRHP listing
• John Clark House (Clarksdale, Mississippi), NRHP-listed
• John Hector Clark House, Clarkton, NC, listed on the NRHP in Bladen County, North Carolina
• Jonathan Clark House, Mequon, Wisconsin, listed on the NRHP in Ozaukee County, Wisconsin