John Blake may refer to:

• John Blake Jr. (1947–2014), American jazz violinist
• John Blake (journalist) (born 1948), British journalist and publisher
• John Blake (make-up artist), 1992 Academy Award nominated makeup artist
• John Blake, fictional character in the 2012 film The Dark Knight Rises

• John Blake (Leicester MP) in 1340 represented Leicester (UK Parliament constituency)
• John Blake (Winchester MP), MP for Winchester
• John Blake (MP for Calne), MP for Calne in 1415
• John Blake fitz William, mayor of Galway in 1487–88
• John Blake Jr. (politician) (1762–1826), United States Representative from New York
• John Aloysius Blake (1826–1887), British politician, Member of Parliament
• John L. Blake (1831–1899), United States Representative from New Jersey
• John Blake (Pennsylvania politician) (born 1960), Member of the Pennsylvania State Senate

• J. P. Blake (John Percy Blake, 1874–1950), British Olympic fencer
• Jere Blake (John Blake, 1875–1933), Wales rugby player
• Bandsman Jack Blake (1890–1960), British boxer born John Blake
• John Blake (cricketer) (1917–1944), English cricketer
• John Blake (rugby union) (1933–1982), Bristol rugby player and teacher
• John Blake (hurler) (born 1957), Irish retired hurler
• John Blake (American football) (1961–2020), American football coach
• John Vaughn Blake (1888–1964), American football player and FBI agent

• John Blake (soldier) (1856–1907), Irish-American soldier and adventurer
• John Bradby Blake (1745–1773), British botanist
• John F. Blake (1922–1995), American intelligence official
• John Frederick Blake (1839–1906), British geologist and clergyman
• John Henry Blake (1808–1882), Irish land agent
• John Lauris Blake (1788–1858), American clergyman and author
• John T. Blake (c. 1901–1987), American research scientist
• John Thomas Blake (1853–1940), New Zealand surveyor, interpreter, land agent, historian, racehorse owner and trainer
• John Rennie Blake (1825–1900), faculty chairman in charge of Davidson College, 1871–1877

• John Blake House, 1794 built and 1984 registered historic house in New York, named after John Blake, Jr. (politician)
• Jon Blake (disambiguation)
• John Blake Dillon (1814–1866), Irish writer and politician