The J.E. Squiers House, also known as the Squiers Manor Bed and Breakfast, is a historic building located in Maquoketa, Iowa, United States. The architectural and historic significance of this house is attributed to its being "a well-preserved example of late nineteenth century domestic architecture in Maquoketa's most prominent residential neighborhood and for its association with the life and career of James Emery Squiers, a prominent local businessman."^[2] Built in 1882, the 21⁄2-story brick house features elements consistent with the Queen Anne and Stick styles. It follows a central hall floor plan with two rectangular projecting bays, a three-sided bay window, a kitchen addition on the back, and a hipped roof with intersecting gable sections.

Squiers ran a dry goods business downtown, which he sold in 1885. He was elected president of the First National Bank of Maquoketa, a position he held until two months before his death in 1911. There was no mortgage to pay for the construction of this house, which attests to the Squiers' wealth.^[2] The house was included as a contributing property in the West Pleasant Street Historic District in 1991, and it was individually listed on the National Register of Historic Places in 1995.^[1]