Human sexual response or Sexual response may refer to:

• Human sexual arousal
• Human Sexual Response, a 1966 book by Masters and Johnson
• Human sexual response cycle, a four-stage model of physiological responses during sexual stimulation first described by Masters and Johnson
• Human sexual function
• Human Sexual Response (band), a new wave musical group from Boston, Massachusetts, United States
• Sexual Response (film), a 1992 American erotic thriller