Hot Stuff may refer to:

• Hot Stuff (1912 film), a 1912 film starring Mabel Normand
• Hot Stuff (1929 film), a 1929 film starring Alice White, Louise Fazenda, and William Bakewell
• Hot Stuff (1956 film), a 1956 short subject starring the Three Stooges
• Hot Stuff (1971 film), a 1971 National Film Board of Canada animated short
• Hot Stuff (1979 film), a 1979 film starring Dom DeLuise, Suzanne Pleshette, and Jerry Reed

• Hot Stuff (album), a 1984 album by La Mafia
• Hot Stuff, a 1988 album by Buck Clarke
• "Hot Stuff (Let's Dance)", a 2007 song by Craig David from Trust Me
• "Hot Stuff" (Donna Summer song), a 1979 song from Bad Girls
• "Hot Stuff" (Rolling Stones song) from Black and Blue
• "Hot Stuff" (Kumi Koda song), Kumi Koda's 15th domestic single
• "Hot Stuff", a song by Ashlee Simpson from Bittersweet World
• "Hot Stuff", a song by Whitesnake from Come an' Get It
• "Hot Stuff", a song by Krokus from The Blitz
• "Hot Stuff", a song by Davichi from My Fair Lady

• Eddie Gilbert (wrestler) (1961–1995), American wrestler known as "Hot Stuff" Eddie Gilbert
• "Hot Stuff", the 159th episode of Happy Days where the original Arnold's was burned down
• Hot Stuff (aircraft), American aircraft during World War II
• Hot Stuff the Little Devil, a Harvey Comics character
• "Hot Stuff", the 94th episode of Family Matters