Horus Heresy may refer to:
- The Horus Heresy, a Warhammer 40,000 novel series
- Horus Heresy (1993 board game), a Warhammer 40,000 board game
- Horus Heresy (2010 board game), a Warhammer 40,000 board game
- Horus Heresy (card game), a Warhammer 40,000 card game
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