Holy Cross School may refer to:

• Holy Cross Catholic Secondary School (St. Catharines), Ontario
• Holy Cross Catholic Secondary School, Kingston, Ontario
• Holy Cross High School (Saskatoon), Saskatchewan
• Holy Cross Regional High School, Surrey, British Columbia
• Holy Cross Secondary School (Peterborough), Ontario

• Holy Cross Convent High School, Thane, Maharashtra
• Holy Cross High School (Kurla), Mumbai, Maharashtra
• Holy Cross School, Bokaro, Bokaro Steel City, Jharkhand

• Holy Cross (Belfast), Northern Ireland, primary school picketed by loyalists
• Holy Cross Catholic High School, Chorley, Lancashire, England
• Holy Cross College (UK), Bury, Greater Manchester, England
• Holy Cross High School, Hamilton, South Lanarkshire, Scotland
• Holy Cross RC Primary School, Bristol, England
• Holy Cross Preparatory School, Kingston upon Thames, England
• Holy Cross School, New Malden, Kingston upon Thames, England

• Holy Cross High School (Connecticut), Waterbury, Connecticut
• Holy Cross High School (River Grove, Illinois)
• Cathedral High School (Indianapolis), Indiana
• Holy Cross High School (Covington, Kentucky)
• Holy Cross High School (Louisville), Kentucky
• Holy Cross School (New Orleans), Louisiana
• Academy of the Holy Cross, Kensington, Maryland
• Hellenic College Holy Cross Greek Orthodox School of Theology, Brookline, Massachusetts
• Holy Cross Catholic School, Marine City, Michigan, a K-8 school
• Holy Cross High School (Marine City, Michigan)
• Holy Cross High School (New Jersey), Delran, New Jersey
• Holy Cross School, Bronx, New York
• Holy Cross School (Manhattan), New York
• Holy Cross High School (Queens), New York
• Holy Cross School (Philadelphia), Pennsylvania
• Holy Cross High School (Pennsylvania), Dunmore, Pennsylvania
• Holy Cross High School (San Antonio, Texas)
• Holy Cross Regional Catholic School (Lynchburg, Virginia)

• Holy Cross College, Ryde, New South Wales, Australia
• Holy Cross Girls' High School (Dhaka), Bangladesh
• Holy Cross High School (Bandura), Bangladesh
• Holy Cross School, Henderson, New Zealand
• Holy Cross High School, Philips, Bukidnon, Philippines
• Holy Cross High School (Cape Town), the Western Cape
• Holy Cross School (Papatoetoe), New Zealand

• HCHS (disambiguation)
• HCS (disambiguation)
• Holy Cross (disambiguation)
• Holy Cross College (disambiguation)
• Holy Cross Convent School (disambiguation)