George Scha(e)f(f)er may refer to:

• George J. Schaefer (1888–1981), American film producer and studio executive
• George Schaefer (finance), American banking executive
• George Schaefer (director) (1920–1997), American television and theatre director and president of the Directors Guild of America
• George Schaefer (businessman) (1928–2013), American businessman, CEO of Caterpillar Inc.
• George Schaefer (bishop) (born 1950), bishop of the Russian Orthodox Church Outside of Russia
• George Schaeffer, American football player
• George C. Schaeffer (1814–1873), American engineer, chemist, and librarian
• George E. Schafer (1922–2015), United States Air Force surgeon general
• Georg Schäfer (industrialist) (1896–1975), German industrialist and art collector
• Georg Schäfer (artist) (1926–1991), German-American painter
• Georg Anton Schäffer (1779–1836), German physician
• George Schaefer (baseball) (born 1989), American baseball coach and pitcher