George Cooper may refer to:

• George Cooper (Poole MP) (1626–1689), English politician
• George Cooper (Canadian politician) (born 1941), Canadian Member of Parliament for Halifax, 1979–1980
• George Cooper (Bermondsey MP) (1844–1909), Member of Parliament for Bermondsey, 1906–1909
• George B. Cooper (politician) (1808–1866), U.S. Representative from Michigan
• George W. Cooper (1851–1899), U.S. Representative from Indiana
• George Cooper (public servant) (1793–1867), first Colonial Treasurer of New Zealand

• George Cooper (American football) (born 1984), American football player
• George Cooper (cricketer) (1907–2000), Australian cricketer
• George Cooper (umpire) (1907–1980), Australian cricket Test match umpire
• George E. Cooper, head coach of American college football teams in the 1920s
• George Cooper (footballer, born 1932) (1932–1994), English footballer for Crystal Palace and Rochdale
• George Cooper (footballer, born 1996), English footballer for Plymouth Argyle
• George Cooper (footballer, born 2002), English footballer for Mansfield Town

• Sir George Cooper (British Army officer) (1925–2020), Adjutant-General to the Forces in the United Kingdom
• George Franklin Cooper, United States Navy officer
• George H. Cooper (1821–1891), United States Navy rear admiral

• George Cooper, Sr., character in Young Sheldon, Sheldon's father
• George Cooper, Jr., character in Young Sheldon, Sheldon's brother
• George Cooper (Tortallan character), fictional character from Tamora Pierce's Tortall novels

• George Cooper (actor) (1892–1943), American actor of the silent era
• George Cooper (organist) (1820–1876), English organist
• George Cooper (poet) (1840–1927), American poet
• George A. Cooper (1925–2018), British actor
• George A. Cooper (director) (1894–1947), British screenwriter and film director
• George B. Cooper (historian) (1916–1995), American historian of British history
• George S. Cooper (1864–1929), American architect
• Buster Cooper (George Cooper, 1929–2016), American jazz trombonist
• Felix Morrow (1906–1988), American political activist and publisher, who used "George Cooper" as a pseudonym in the early 1930s