GTC may refer to:

• General Teaching Council (disambiguation)
• Gateway Technical College, in Wisconsin, United States
• Green Templeton College, Oxford, a constituent college of the University of Oxford
• Greenville Technical College, in South Carolina, United States
• Griffin Technical College, now part of Southern Crescent Technical College, in Georgia, United States
• Gwinnett Technical College, in Georgia, United States
• Government Tolaram College, in Narayanganj, Bangladesh

• Generalised tonic-clonic seizure
• Graceful tree conjecture
• Gran Telescopio Canarias, a Spanish telescope
• Gigatonnes of carbon (GtC)
• GTC, a codon for the amino acid valine

• Game time card, in online gaming
• Genome Therapeutics Corporation, a defunct American biotech company
• GPU Technology Conference, an annual technical conference started by Nvidia in 2009
• Opel GTC, a concept car
• General Technologies Corp., a Canadian manufacturer of diagnostic and test equipment for vehicles
• Giant Tech Companies, big technology companies like Facebook, Google, etc

• Generic Token Card, in wireless and point-to-point communications
• Grameen Telecom, a Bangladeshi telecommunications company
• GTC Wireless, an American telecommunications company

• Gauhati Town Club, an Indian sports club
• General Trade Company, a defunct Dano-Norwegian trading company
• GeTai Challenge, abbreviated as GTC, a Singaporean reality singing competition for getai singers organised by MediaCorp
• Girls' Training Corps, a former British girls' voluntary organisation
• Global Trade Center, a shopping, residential and hotel complex in Nairobi
• Going to California (TV series)
• Good 'til cancelled, an investment order
• Gran Turismo Concept, a video game
• Sasol GTC Championship, a South African motorsport championship
• Grand Traverse County, in Michigan, United States
• Grand Trunk Corporation, a Canadian National Railway subsidiary
• Ground Training Competition, of the Royal Air Force
• Grudge Training Center, a mixed martial arts training center in Colorado, United States
• Ground Transportation Center, a transit center within an airport providing ground transportation, such as buses, trains, taxies, to the city
• Guild of Television Camera Professionals an organisation for professional camera people