GPT may refer to:

• Generative pre-trained transformer, a type of artificial intelligence language model
  • ChatGPT, a chatbot developed by OpenAI, based on generative pre-trained transformer technology
• GUID Partition Table, a computer storage disk partitioning standard

• Alanine transaminase or glutamate pyruvate transaminase
• Goniopora toxin
• UDP-N-acetylglucosamine—undecaprenyl-phosphate N-acetylglucosaminephosphotransferase

• GEC Plessey Telecommunications, a defunct British telecommunications manufacturer
• GPT Group, an Australian property investment company
• GPT, subsidiary of Airbus SE

• Gulfport–Biloxi International Airport, in Mississippi
• General-purpose technology, in economics
• Generalized probabilistic theory, a framework to describe the features of physical theories
• Grounded practical theory, a social science theory
• GPT, a song on the album ...l, by Korean girl group STAYC