GDC may refer to:

• Democratic Group of the Centre (Romanian: Grupul Democrat de Centru), a political party in Romania
• Gabriel Dumont College, now Gabriel Dumont Institute, in Saskatchewan, Canada
• Gambia Democratic Congress, a political party in the Gambia
• General Development Corporation, a defunct American real estate company
• General Dental Council in the United Kingdom
• Genstar Development Company, a Canadian real estate developer
• Georgia Department of Corrections, of the U.S. state of Georgia
• Geothermal Development Company, in Kenya
• Giordano Dance Chicago, an American dance company
• Government degree colleges in India
• Gravity Discovery Centre, in Gingin, Western Australia
• Society of Graphic Designers of Canada
• Virginia General District Court

• Gadolinium-doped ceria
• Game Developers Conference, an annual video game conference
• Graphic Display Calculator
• Guglielmi detachable coil
• GDC, a compiler for the D programming language

• Donaldson Center Airport, Greenville, South Carolina, United States
• Gross dealer concession
• Global Digital Compact, an initiative in the United Nations