Francisco Pizarro was a 16th-century Spanish conquistador who conquered Peru.
Francisco Pizarro may also refer to:
- Francisco Pizarro (Chilean footballer), Chilean football forward
- Francisco Pizarro (Peruvian footballer), Peruvian football manager and former goalkeeper
- Francisco Pizarro Martínez, Mexican diplomat
- Francisco Pizarro, Nariño, municipality in the Nariño Department, Colombia
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