Francisco Fernández may refer to:

• Francisco Fernández de la Cueva, 2nd Duke of Alburquerque (1467–1526), Spanish noble
• Francisco Fernández de la Cueva, 4th Duke of Alburquerque (1510–1563), Spanish noble
• Francisco Fernández de la Cueva, 7th Duke of Alburquerque (1575–1637), Spanish noble
• Francisco Fernández de la Cueva, 8th Duke of Alburquerque (1619–1676), Spanish military officer and governor of New Spain
• Francisco Fernández de la Cueva, 10th Duke of Alburquerque (1666–1724), viceroy of New Spain

• Francisco Montealegre Fernández (1818–1875), Costa Rican politician and businessman
• Francisco Fernández de Béthencourt (1850–1916), Spanish politician
• Francisco Fernández Ordóñez (1930–1992), Spanish politician
• Francisco Fernández Marugán (born 1946), Spanish politician
• Francisco Fernández de Cevallos (born 1947), Mexican politician
• Francisco Sanz Fernández (born 1952), Spanish politician
• Francisco Javier Fernández (politician) (born 1969), Spanish politician

• Gallego (footballer) (Francisco Fernández Rodríguez, born 1944), Spanish international footballer of the 1960s
• Francisco Fernández Ochoa (1950–2006), Spanish alpine skier
• Francisco Fernández Moreno (born 1954), Spanish road bicycle racer
• Francisco Fernández (Chilean footballer) (born 1975), Chilean association football player
• Paquillo Fernández (Francisco Javier Fernández, born 1977), Spanish racewalker
• Francisco Fernández (water polo) (born 1986), Spanish water polo player

• Francisco Fernández (artist) (1606–1646), Spanish painter
• Francisco Fernández Carvajal (born 1938), Spanish priest
• Francisco Moreno Fernández (born 1960), Spanish dialectologist and sociolinguist
• Francisco Fernández (supercentenarian) (1901–2012), Spanish supercentenarian

• Francisco José Fernandes Costa (1867–1925), member of the Portuguese Republican Party
• Frank Fernández (disambiguation)
• Francisco Javier Fernández (disambiguation)