Fraine is a surname.
Notable people with the surname include:
- Ethel de Fraine (1879-1918), British botanist
- Greg Fraine (born 1962), New Zealand cyclist
- John H. Fraine (1861-1943), Lieutenant Governor of North Dakota
- Katie Fraine (born 1987), American soccer player
- Will Fraine (born 1996), English cricketer
See also
- Fraine, an Italian commune
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