EPL may refer to:

• Easy Programming Language
• Eclipse Public License
• Eltron Programming Language, a control language for various computer printers
• Ethernet Powerlink, an Ethernet protocol
• Early PL/I, a PL/I subset dialect used to write Multics

• Extensor pollicis longus muscle
• External plexiform layer

• École polytechnique de Louvain, faculty of engineering science at the University of Louvain (UCLouvain), Belgium

• Edmonton Public Library, in Alberta, Canada
• Euclid Public Library, in, Ohio, United States
• Evanston Public Library, in Illinois, United States
• Everett Public Library, in Washington, United States

• EPL (journal), a scientific journal
• Eesti Päevaleht, an Estonian newspaper

• Egyptian Premier League
• English Premier League
• ESL Pro League, a professional Counter-Strike: Global Offensive league
• Everest Premier League, a Nepali cricket league

• Edinburgh Partners, a Scottish investment firm
• El Pollo Loco, an American restaurant chain
• Employment practices liability
• Employment protection legislation
• Escola Portuguesa de Luanda, a Portuguese international school in Angola
• Popular Liberation Army (Spanish: Ejército Popular de Liberación), a Colombian guerrilla group