EMD may refer to:

• Earnest money deposit, in the United States, a security deposit, especially for real estate

• Electromagnetic diaphragm
• Electromechanical dissociation
• Emergency medical dispatcher
• Enamel matrix derivative
• Esophageal motility disorder
• Merck Group, known as EMD in Canada and the United States, a German pharmaceutical company

• Electrolytic manganese dioxide
• Emerin
• Empirical mode decomposition
• Equilibrium mode distribution
• ReadyBoost, disk-caching software

• East Midlands Parkway railway station, in England
• Electro-Motive Diesel, an American locomotive manufacturer
• Electronic Miscellaneous Document in the airline industry
• Emerald Airport, in Queensland, Australia

• Schneider Electric EMD an Armenian-Serbian electric company
• EMD (band), a Swedish band
• Earth mover's distance
• European Marketing Distribution, a European purchasing organization for grocery stores
• European Maritime Day
• Engineering and Manufacturing Development, a U.S. defense acquisition phase associated with detailed design and subsequent testing to verify requirements; previously called Full-Scale Development (FSD)