De Valera or Valera is a surname of Spanish origin. It may refer to:

• Cipriano de Valera (1531–1602), Spanish Protestant refugee
• Diego de Valera (1412–1488), Spanish writer
• Éamon de Valera (1882–1975), Irish statesman
• José Vincente de Valera (1822–1899), Spanish Army officer
• Máirin de Valéra, (1912–1984), Irish phycologist
• Rúaidhrí de Valera (1916–1978), Irish archaeologist
• Síle de Valera (born 1954), Irish Fianna Fáil politician
• Sinéad de Valera (1878–1975), wife of Éamon de Valera
• Vivion de Valera (1910–1982), Irish Fianna Fáil politician

• Valera (disambiguation), which includes a list of people with the surname
• Varela