General Confederation of Labour can mean one of the following labor unions:

• Italian General Confederation of Labour (CGIL)
• Central General de Trabajadores (Dominican Republic), a trade union in the Dominican Republic
• Central General de Trabajadores (Honduras), a trade union in Honduras
• General Confederation of Labour of Luxembourg, a trade union federation in Luxembourg
• General Confederation of Workers (Mexico) (Confederación General de Trabajadores), a Mexican trade union
• General Confederation of Workers (Puerto Rico) (CGT)
• General Confederation of Labour (Spain), (CGT) a Spanish anarchosyndicalist trade union
• Confédération Générale du Travail, (CGT) one of the largest French confederations of trade unions
• General Confederation of Labour (Argentina), the largest labor federation in Argentina
• Confederação Geral dos Trabalhadores, a Brazilian trade union
• General Confederation of Labour (Portugal), a Portuguese trade union
• Vietnam General Confederation of Labour, a Vietnamese trade union