Cinfenine (INNTooltip International Nonproprietary Name) is a drug described as an antidepressant and coronary vasodilator which was never marketed.[1][2][3] It was first described in the literature by 1970.[1][4] The drug is similar in chemical structure to the modafinil derivative and atypical dopamine reuptake inhibitor JJC8-016, as well as to the antihistamine and anticholinergic diphenhydramine and derivatives of diphenhydramine like ebastine.[1][5] Other notable analogues acting as dopamine reuptake inhibitors have been synthesized as well.[6]

See also

References

  1. ^ a b c Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 278. ISBN 978-1-4757-2085-3. Retrieved 20 October 2024.
  2. ^ Use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances (PDF). World Health Organization. 2024. p. 102. ISBN 978-92-4-009938-8.
  3. ^ "CINFENINE". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS). Retrieved 20 October 2024.
  4. ^ DE 1936206, "Diphenylmethoxyaethylaminoderivate und Verfahren zu ihrer Herstellung", published 22 January 1970, assigned to Koninklijke Pharmaceutische Fabrieken NV 
  5. ^ "Cinfenine". PubChem. U.S. National Library of Medicine. Retrieved 20 October 2024.
  6. ^ Hsin LW, Prisinzano T, Wilkerson CR, Dersch CM, Horel R, Jacobson AE, et al. (February 2003). "Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents". Bioorg Med Chem Lett. 13 (3): 553–556. doi:10.1016/s0960-894x(02)00940-x. PMID 12565970.


Allikas: https://en.wikipedia.org/wiki/Cinfenine
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