CLI may refer to:

• Call Level Interface, an SQL database management API
• Command-line interface, of a computer program
• Command-line interpreter or command language interpreter; see List of command-line interpreters
• CLI (x86 instruction)
• ISO Common Language Infrastructure for multi-platform code (.Net)

• Caribbean Law Institute
• Charlotte Lozier Institute, research arm of anti-abortion group Susan B. Anthony Pro-Life America
• Clì Gàidhlig, an organisation supporting learners of Scottish Gaelic
• Clintonville Municipal Airport with airport code "CLI"
• Committee for the Liberation of Iraq
• Corps Léger d'Intervention, special forces in the Far East French Expeditionary Corps

• 151 (number), in Roman numerals
• Canada Land Inventory
• Cebu Landmasters, Philippine stock exchange code CLI
• Critical limb ischemia
• Telephone Caller Line Identification (Caller ID)

• Clicli, a character in Marine Boy