Antietam /ænˈtiːtəm/ may refer to:

• Antietam, Maryland, an unincorporated community four miles south of the battlefield of the Battle of Antietam
  • Antietam Iron Furnace Site and Antietam Village
• Antietam Hall
• Antietam Creek, a tributary of the Potomac River in Pennsylvania and Western Maryland; source name for the battle
• Antietam National Battlefield, an American national park

• Antietam Creek (Schuylkill River), a tributary of the Schuylkill River
• Antietam Lake, a reservoir in Berks County

• Antietam (band), US indie rock band
• "Antietam", a song by Billy Corgan
• Antietam: The Bloodiest Day, 17 September 1862, a 1975 board wargame that simulates the American Civil War Battle
• Battleground 5: Antietam, a strategy computer game
• Sid Meier's Antietam!, a tactical computer game

• Battle of Antietam, a major American Civil War battle
• Maryland Campaign, also known as the Antietam Campaign, an American Civil War invasion
• USS Antietam, three US Navy ships