The 1980 African Cup of Champions Clubs was the 16th edition of the annual international club football competition held in the CAF region (Africa), the African Cup of Champions Clubs. It determined that year's club champion of association football in Africa.

The tournament was played by 31 teams and was used a playoff scheme with home and away matches. Canon Yaoundé from Cameroon won that final, and became for the third time CAF club champion.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
AS Niamey	0–3	Djoliba AC	0–1	0–2
Anges ABC	4–5	Hearts of Oak	2–3	2–2
Bendel Insurance	w/o1	UCB FC	—	—
Benfica de Bissau	2–7	Stella Adjamé	0–4	2–3
Canon Yaoundé	7–3	Primeiro de Agosto	3–0	4–3
Costa do Sol	1–3	AS Bilima	0–0	1–3
Dragons de l'Ouémé	0–3	MP Alger	0–0	0–3
CD Elá Nguema	1–4	AC Semassi	1–0	0–4
Fortior Mahajanga	w/o1	Limbe Leaf Wanderers	—	—
ASC Garde Nationale	1–3	Hafia FC	1–1	0–2
Horseed FC	0–2	Gor Mahia	0–0	0–2
Linare FC	2–4	Simba SC	2–1	0–3
Mighty Blackpool	1–4	ASF Police	1–2	0–2
Olympic Real de Bangui	1–4	Etoile du Congo	0–1	1–3
Wallidan FC	1–2	Silures Bobo-Dioulasso	1–1	0–1

¹ UCB FC and Limbe Leaf Wanderers withdrew.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
AS Bilima	4–1	Fortior Mahajanga	3–0	1–1
Bendel Insurance	4–4 (a)	Gor Mahia	1–2	3–2
Djoliba AC	1–2	Hearts of Oak	1–1	0–1
Etoile du Congo	1–1 (3–1 p)	Hafia FC	0–1	1–0
AC Semassi	1–2	ASF Police	1–1	0–1
Silures Bobo-Dioulasso	0–4	Canon Yaoundé	0–1	0–3
Simba SC	2–5	Union Douala	2–4	0–1
Stella Adjamé	5–5 (a)	MP Alger	4–2	1–3

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Canon Yaoundé	3–3 (a)	MP Alger	2–0	1–3
Etoile du Congo	3–3 (a)	Bendel Insurance	3–2	0–1
Hearts of Oak	1–4	AS Bilima	1–3	0–1
ASF Police	3–5	Union Douala	0–3	3–2

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Canon Yaoundé	4–2	Bendel Insurance	0–0	4–2
Union Douala	2–5	AS Bilima	1–0	1–5

30 November 1980

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Canon Yaoundé	2–2	AS Bilima
		Ayel Yafu

Stade de Garoua, Garoua

14 December 1980

--:-- UTC+1

AS Bilima	0–3	Canon Yaoundé
		Manga Onguéné Abega

20 May Stadium, Kinshasa

African Cup of Champions Clubs 1980 Canon Yaoundé Third title

The top scorers from the 1980 African Cup of Champions Clubs are as follows:

Rank	Name	Team	Goals
1	Jean Manga Onguéné	Canon Yaoundé	9
2	Ayel Mayélé	AS Bilima	5
3	Lakhdar Belloumi	MP Alger	4
	Ibrahim Alikali	Bendel Insurance	4
5	Théophile Abega	Canon Yaoundé	3
	Andrew Obunga	Gor Mahia	3
7	Abdelwahab Zenir	MP Alger	2
	Grégoire M'Bida	Canon Yaoundé	2
	... Tchibundo	Anges ABC	2
	Dan Kayede	Hearts of Oak	2
	Léon Gbizié	Stella Club d'Adjamé	2
	Francis Doé	Stella Club d'Adjamé	2
	Jean Mandiangu	AS Bilima	2

• Champions' Cup 1980 - rsssf.com