5M or 5-M may refer to:
- 5M model, a troubleshooting and risk-management model used for aviation safety
- Sibaviatrans (IATA code), a former airline
- 5M, a Toyota M engine
- 5M, a model of HP LaserJet 5
- Shada (Doctor Who) (production code: 5M), an unfinished Doctor Who serial
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