Ons Jabeur won the singles tennis title at the 2022 German Open after Belinda Bencic retired with an ankle injury from the final with the score at 6–3, 2–1.^[1]

Liudmila Samsonova was the defending champion,^[2] but lost in the second round to Veronika Kudermetova.^[3]

	Semifinals							Final
	1	Ons Jabeur	77	6
	7	Coco Gauff	64	2
								1	Ons Jabeur	6	2
								8	Belinda Bencic	3	1r
	8	Belinda Bencic	66	6	6
	2	Maria Sakkari	78	4	4

	First round							Second round							Quarterfinals							Semifinals
	1	O Jabeur	6	6
	PR	K Muchová	3	3				1	O Jabeur	6	710
		Q Zheng	3	64				Q	A Parks	2	68
	Q	A Parks	6	77											1	O Jabeur	63	6	6
	Q	A Gasanova	2	6	3											A Sasnovich	77	2	2
		A Sasnovich	6	4	6				A Sasnovich	6	6
		A Petkovic	710	6					A Petkovic	4	4
	5	G Muguruza	68	4																		1	O Jabeur	77	6
	4	Ka Plíšková	65	6	6																	7	C Gauff	64	2
		K Kanepi	77	0	0			4	Ka Plíšková	6	2	79
		K Siniaková	4	6	4			PR	B Andreescu	4	6	67
	PR	B Andreescu	6	4	6										4	Ka Plíšková	5	4
	Q	T Korpatsch	6	3	4										7	C Gauff	7	6
	Q	Xin Wang	3	6	6			Q	Xin Wang	0	4
		A Li	2	62				7	C Gauff	6	6
	7	C Gauff	6	77

	First round							Second round							Quarterfinals							Semifinals
	8	B Bencic	6	5	6
	WC	J Niemeier	4	7	3			8	B Bencic	6	1	6
	WC	A Kalinskaya	6	6				WC	A Kalinskaya	4	6	1
		A Cornet	4	4											8	B Bencic	3	6	6
		T Zidanšek	5	1												V Kudermetova	6	3	3
		L Samsonova	7	6					L Samsonova	3	77	1
		V Kudermetova	2	7	6				V Kudermetova	6	65	6
	3	A Sabalenka	6	5	4																	8	B Bencic	66	6	6
	6	D Kasatkina	5	6	6																	2	M Sakkari	78	4	4
		A Kalinina	7	3	1			6	D Kasatkina	5	6	6
		M Zanevska	3	4					E Alexandrova	7	1	1
		E Alexandrova	6	6											6	D Kasatkina	0	3
		J Teichmann	77	5	2										2	M Sakkari	6	6
	Q	D Saville	62	7	6			Q	D Saville	1	5
	Q	L Jeanjean	3	2				2	M Sakkari	6	7
	2	M Sakkari	6	6

	First round							Qualifying competition
	1	Wang Xinyu	6	6
	Alt	Ekaterina Kazionova	4	1
								1	Wang Xinyu	4	6	6
								WC	Anna-Lena Friedsam	6	3	3
	WC	Anna-Lena Friedsam	6	3	6
	10	Suzan Lamens	3	6	4

	First round							Qualifying competition
	2/PR	Daria Saville	7	6
	WC	Noma Noha Akugue	5	4
								2/PR	Daria Saville	6	79
								WC	Sabine Lisicki	0	67
	WC	Sabine Lisicki	6	6
	7	Asia Muhammad	4	4

	First round							Qualifying competition
	3	Tamara Korpatsch	6	6
	Alt	Lena Papadakis	2	3
								3	Tamara Korpatsch	79	6
									Storm Sanders	67	0
		Storm Sanders	6	6
	8	Nastasja Schunk	1	2

	First round							Qualifying competition
	4	Kamilla Rakhimova	6	6
		Isabella Shinikova	3	4
								4	Kamilla Rakhimova	6	4	4
								9	Alycia Parks	2	6	6
		Ulrikke Eikeri	3	4
	9	Alycia Parks	6	6

	First round							Qualifying competition
	5/WC	Léolia Jeanjean	6	6
		Natalija Stevanović	2	4
								5/WC	Léolia Jeanjean	6	77
								12	Stefanie Vögele	3	65
	PR	Han Xinyun	1	5
	12	Stefanie Vögele	6	7

	First round							Qualifying competition
	6	Anastasia Gasanova	4	78	6
		Eva Lys	6	66	2
								6	Anastasia Gasanova	7	6
								11	Nigina Abduraimova	5	2
		Ekaterina Makarova	6	5	4
	11	Nigina Abduraimova	3	7	6

• Main draw
• Qualifying draw