Barbora Krejčíková defeated Anastasia Pavlyuchenkova in the final, 6–1, 2–6, 6–4 to win the women's singles tennis title at the 2021 French Open.^[1] It was her first major singles title.^[2] Krejčíková saved a match point en route to the title, in the semifinals against Maria Sakkari. Krejčíková and Pavlyuchenkova were the combined lowest-ranked major finalists (numbers 33 and 32, respectively) since the introduction of the computer rankings in 1975 (a feat surpassed just three months later at the US Open).

Krejčíková was the first Czech woman to win the title since Hana Mandlíková in 1981.^[a] She was also the first player to win both the singles and doubles titles at the same major since Serena Williams at the 2016 Wimbledon Championships, and the first to do so at the French Open since Mary Pierce in 2000. Pavlyuchenkova reached her first major final after participating in 52 major main draws, breaking the record previously set by Flavia Pennetta in the 2015 US Open.^[3]

Iga Świątek was the defending champion, but lost to Sakkari in the quarterfinals. Świątek's loss marked the 14th consecutive year where the reigning French Open champion failed to defend their title, with Justine Henin being the last woman to do so in 2007 (Świątek would end this stretch herself two years later).^[4] It ensured the sixth consecutive French Open to feature a first-time major champion.^[5] Świątek's loss also ensured that this was the first French Open and the third major in the Open Era to feature all first-time major semifinalists,^[6] and it was the first major in the Open Era in which six players made their major quarterfinal debuts.^[7]

Ashleigh Barty and Naomi Osaka were in contention for the world No. 1 singles ranking. Barty retained the top ranking after Osaka withdrew from the second round.^[8]

Serena Williams was the oldest woman in the Open Era to reach the fourth round; this was also the three-time champion's final French Open appearance before retiring from professional tennis the following year.^[9][10] Sakkari and Tamara Zidanšek became the first Greek woman and Slovenian player to reach the singles quarterfinals and semifinals of a major, respectively.^[11][12][b] Coco Gauff was the youngest player to reach a major quarterfinal since Nicole Vaidišová at the 2006 French Open.^[13]

Click on the seed number of a player to go to their draw section.

	Quarterfinals							Semifinals							Final
	24	Coco Gauff	66	3
		Barbora Krejčíková	78	6
									Barbora Krejčíková	7	4	9
								17	Maria Sakkari	5	6	7
	17	Maria Sakkari	6	6
	8	Iga Świątek	4	4
																Barbora Krejčíková	6	2	6
															31	Anastasia Pavlyuchenkova	1	6	4
	21	Elena Rybakina	77	2	7
	31	Anastasia Pavlyuchenkova	62	6	9
								31	Anastasia Pavlyuchenkova	7	6
									Tamara Zidanšek	5	3
		Tamara Zidanšek	7	4	8
	33	Paula Badosa	5	6	6

	First round							Second round							Third round							Fourth round
	1	A Barty	6	3	6
		B Pera	4	6	2			1	A Barty	1	2r
		M Linette	6	6					M Linette	6	2
	WC	C Paquet	3	3												M Linette	6	0	1
	Q	I Bara	65	2											25	O Jabeur	3	6	6
	WC	A Sharma	77	6				WC	A Sharma	2	4
		Y Putintseva	5	2				25	O Jabeur	6	6
	25	O Jabeur	7	6																		25	O Jabeur	3	1
	24	C Gauff	713	6																		24	C Gauff	6	6
	Q	A Krunić	611	4				24	C Gauff	6	77
		Q Wang	2	6	7				Q Wang	3	61
		S-w Hsieh	6	4	5										24	C Gauff	6	0
	Q	E-s Liang	1	6	4										13	J Brady	1	0r
		F Ferro	6	1	6				F Ferro	4	6	5
		A Sevastova	3	3				13	J Brady	6	2	7
	13	J Brady	6	6

	First round							Second round							Third round							Fourth round
	9	Ka Plíšková	7	6
		D Vekić	5	4				9	Ka Plíšková	5	1
		C Suárez Navarro	6	64	4				S Stephens	7	6
		S Stephens	3	77	6											S Stephens	6	7
	Q	V Lepchenko	6	6											18	K Muchová	3	5
		S Zhang	3	3				Q	V Lepchenko	3	4
	PR	A Petkovic	6	3	4			18	K Muchová	6	6
	18	K Muchová	1	6	6																		S Stephens	2	0
	32	E Alexandrova	6	6																			B Krejčíková	6	6
		V Williams	3	1				32	E Alexandrova	2	3
		B Krejčíková	5	6	6				B Krejčíková	6	6
		Kr Plíšková	7	4	2											B Krejčíková	6	6
		A Li	6	6											5	E Svitolina	3	2
		M Gasparyan	0	1					A Li	0	4
	WC	O Babel	2	5				5	E Svitolina	6	6
	5	E Svitolina	6	7

	First round							Second round							Third round							Fourth round
	4	S Kenin	6	4	6
		J Ostapenko	4	6	3			4	S Kenin	7	6
	Q	H Baptiste	6	6				Q	H Baptiste	5	3
		A Blinkova	1	4											4	S Kenin	4	6	6
		T Martincová	6	78											28	J Pegula	6	1	4
	PR	I Jorović	3	66					T Martincová	3	3
		L Zhu	4	6	4			28	J Pegula	6	6
	28	J Pegula	6	4	6																	4	S Kenin	1	3
	17	M Sakkari	6	6																		17	M Sakkari	6	6
	Q	K Zavatska	4	1				17	M Sakkari	6	6
		J Paolini	7	6					J Paolini	2	3
	Q	S Vögele	5	1											17	M Sakkari	7	62	6
		H Watson	4	5											14	E Mertens	5	77	2
		Z Diyas	6	7					Z Diyas	6	2	4
	Q	S Sanders	4	1				14	E Mertens	4	6	6
	14	E Mertens	6	6

	First round							Second round							Third round							Fourth round
	12	G Muguruza	1	4
		M Kostyuk	6	6					M Kostyuk	6	6
		S Zheng	4	6	6				S Zheng	3	4
		S Sorribes Tormo	6	4	4											M Kostyuk	6	6
	Q	L Arruabarrena	2	3												V Gracheva	1	2
		V Gracheva	6	6					V Gracheva	7	1	6
		C Giorgi	6	65	6				C Giorgi	5	6	2
	22	P Martić	2	77	4																		M Kostyuk	3	4
	30	A Kontaveit	64	77	6																	8	I Świątek	6	6
		V Golubic	77	65	0			30	A Kontaveit	6	6
	Q	AK Schmiedlová	4	0					K Mladenovic	2	0
		K Mladenovic	6	6											30	A Kontaveit	64	0
		R Peterson	63	710	6										8	I Świątek	77	6
		S Rogers	77	68	2				R Peterson	1	1
		K Juvan	0	5				8	I Świątek	6	6
	8	I Świątek	6	7

	First round							Second round							Third round							Fourth round
	7	S Williams	78	6
		I-C Begu	66	2				7	S Williams	6	5	6
		A Rus	5	5				PR	M Buzărnescu	3	7	1
	PR	M Buzărnescu	7	7											7	S Williams	6	6
		D Collins	6	4	6											D Collins	4	4
	Q	Xiy Wang	2	6	4				D Collins	6	6
	Q	A Kalinina	6	6				Q	A Kalinina	0	2
	26	A Kerber	2	4																		7	S Williams	3	5
	21	E Rybakina	6	6																		21	E Rybakina	6	7
	WC	E Jacquemot	4	1				21	E Rybakina	6	6
		N Hibino	77	6					N Hibino	3	1
		N Stojanović	64	2											21	E Rybakina	6	6
	PR	E Vesnina	6	6											PR	E Vesnina	1	4
	LL	O Govortsova	1	0				PR	E Vesnina	w/o
	Q	G Minnen	77	65	1			11	P Kvitová
	11	P Kvitová	63	77	6

	First round							Second round							Third round							Fourth round
	15	V Azarenka	6	2	6
		S Kuznetsova	4	6	3			15	V Azarenka	7	6
		C Tauson	6	6					C Tauson	5	4
	Q	E Gorgodze	4	2											15	V Azarenka	6	6
		L Fernandez	6	6											23	M Keys	2	2
		A Potapova	2	1					L Fernandez	1	5
	WC	O Dodin	3	6	1			23	M Keys	6	7
	23	M Keys	6	3	6																	15	V Azarenka	7	3	2
	31	A Pavlyuchenkova	6	6																		31	A Pavlyuchenkova	5	6	6
		C McHale	4	0				31	A Pavlyuchenkova	6	6
	PR	K Kozlova	2	4					A Tomljanović	2	3
		A Tomljanović	6	6											31	A Pavlyuchenkova	6	2	6
	WC	D Parry	3	6	3										3	A Sabalenka	4	6	0
		A Sasnovich	6	3	6				A Sasnovich	5	3
	Q	A Konjuh	4	3				3	A Sabalenka	7	6
	3	A Sabalenka	6	6

	First round							Second round							Third round							Fourth round
	6	B Andreescu	77	62	7
		T Zidanšek	61	77	9				T Zidanšek	6	6
		M Brengle	7	6					M Brengle	4	1
	Q	C Osorio	5	4												T Zidanšek	0	77	6
		M Bouzková	0	6	2											K Siniaková	6	65	2
		K Siniaková	6	4	6				K Siniaková	79	5	7
		A Anisimova	65	1				29	V Kudermetova	67	7	5
	29	V Kudermetova	77	6																			T Zidanšek	77	6
	19	J Konta	65	2																			S Cîrstea	64	1
		S Cîrstea	77	6					S Cîrstea	6	3	6
		A Van Uytvanck	5	6	4				M Trevisan	4	6	4
		M Trevisan	7	4	6											S Cîrstea	6	6
		D Kasatkina	6	5	6											D Kasatkina	3	2
		M Doi	3	7	3				D Kasatkina	6	6
		N Podoroska	0	3				10	B Bencic	2	2
	10	B Bencic	6	6

	First round							Second round							Third round							Fourth round
	16	K Bertens	1	6	4
		P Hercog	6	3	6				P Hercog	7	6
		L Siegemund	3	1					C Garcia	5	4
		C Garcia	6	6												P Hercog	3	3
		A Cornet	4	4											20	M Vondroušová	6	6
	WC	H Tan	6	6				WC	H Tan	1	3
		K Kanepi	6	3	0			20	M Vondroušová	6	6
	20	M Vondroušová	4	6	6																	20	M Vondroušová	4	6	2
	33	P Badosa	6	77																		33	P Badosa	6	3	6
		L Davis	2	63				33	P Badosa	6	6
	WC	C Burel	3	68					D Kovinić	2	0
		D Kovinić	6	710											33	P Badosa	2	77	6
	LL	E Cocciaretto	1	3												A Bogdan	6	64	4
		A Bogdan	6	6					A Bogdan	w/o
		PM Țig	4	64				2	N Osaka
	2	N Osaka	6	77

Category	Krejčíková	Pavlyuchenkova
1st serve %	58/80 (73%)	53/80 (66%)
1st serve points won	32 of 58 = 55%	26 of 53 = 49%
2nd serve points won	12 of 22 = 55%	13 of 27 = 48%
Total service points won	44 of 80 = 55.00%	39 of 80 = 48.75%
Aces	2	2
Double faults	5	1
Winners	34	23
Unforced errors	31	16
Net points won	11 of 15 = 73%	2 of 6 = 33%
Break points converted	6 of 14 = 43%	5 of 12 = 42%
Return points won	41 of 80 = 51%	36 of 80 = 45%
Total points won	85	75
Source

The following are the seeded players. Seedings are based on WTA rankings as of 24 May 2021. Rankings and points before are as of 31 May 2021. Because the tournament was moved a week and points of the week of 10 June 2019 includes results only from Nottingham. The defending points from 's-Hertogenbosch is not included towards on dropping points.

As a result of pandemic-related adjustments to the ranking system and changes to the WTA Tour calendar in 2020, players will have the following potential adjustments to their ranking points after the tournament:

• Players who are defending points from the 2019 tournament in which are higher will be dropped on 14 June 2021; those points will be replaced by the higher of their points from 2019 or 2020 (points from 2020 will still be valid at the end of the 2021 tournament because the 2020 tournament delayed to four months in the normal scheduled calendar year; both 2019 and 2020 points are equaled within the same result will also be dropped on 11 October 2021).
• Players who are defending points from the 2020 tournament will have those points replaced by 2021 points only if the latter are higher.
• Players who have points from the 2020 tournament still counting towards their ranking on 14 June 2021 will have those points dropped on 11 October 2021 (52 weeks after the 2020 tournament); any 2020 points will be replaced by 2021 points at that time.
• Players who are not defending points from either the 2019 or 2020 tournaments will have their 16th best result replaced by their points from the 2021 tournament.

Note that this is a different ranking adjustment system than the one being used by the ATP for the men's event.

Seed	Rank	Player	Points before	2019 Points	2020 Points	Points won	Points after	Status
1	1	Ashleigh Barty	10,175	2,000	-	70	8,245	Second round retired against Magda Linette
2	2	Naomi Osaka	7,461	130	-	70	7,401	Second round withdrew due to mental health issues
3	4	Aryna Sabalenka	6,195	70	130	130	6,195	Third round lost to Anastasia Pavlyuchenkova [31]
4	5	Sofia Kenin	5,865	240	1,300	240	5,865†	Fourth round lost to Maria Sakkari [17]
5	6	Elina Svitolina	5,835	130	430	130	5,835†	Third round lost to Barbora Krejčíková
6	7	Bianca Andreescu	5,325	70	-	10	5,265	First round lost to Tamara Zidanšek
7	8	Serena Williams	4,821	130	70	240	4,931	Fourth round lost to Elena Rybakina [21]
8	9	Iga Świątek	4,435	240	2,000	430	4,435†	Quarterfinals lost to Maria Sakkari [17]
9	10	Karolína Plíšková	4,345	130	70	70	4,285	Second round lost to Sloane Stephens
10	11	Belinda Bencic	4,140	130	-	70	4,080	Second round lost to Daria Kasatkina
11	12	Petra Kvitová	4,115	0	780	70	4,115†	Second round withdrew due to an ankle injury
12	13	Garbiñe Muguruza	4,110	240	130	10	4,000	First round lost to Marta Kostyuk
13	14	Jennifer Brady	3,830	70+110	10	70+130	3,830	Third round retired against Coco Gauff [24]
14	15	Elise Mertens	3,685	130	130	130	3,685	Third round lost to Maria Sakkari [17]
15	16	Victoria Azarenka	3,526	70	70	240	3,696	Fourth round lost to Anastasia Pavlyuchenkova [31]
16	17	Kiki Bertens	3,220	70	240	10	3,220†	First round lost to Polona Hercog
17	18	Maria Sakkari	2,830	70	130	780	3,480	Semifinals lost to Barbora Krejčíková
18	19	Karolína Muchová	2,816	70	10	130	2,876	Third round lost to Sloane Stephens
19	20	Johanna Konta	2,756	780	10	10	1,986	First round lost to Sorana Cîrstea
20	21	Markéta Vondroušová	2,746	1,300	10	240	1,686	Fourth round lost to Paula Badosa [33]
21	22	Elena Rybakina	2,683	40	70	430	3,043	Quarterfinals lost to Anastasia Pavlyuchenkova [31]
22	23	Petra Martić	2,660	430	130	10	2,360	First round lost to Camila Giorgi
23	24	Madison Keys	2,606	430	10	130	2,306	Third round lost to Victoria Azarenka [15]
24	25	Coco Gauff	2,420	20	70	430	2,780	Quarterfinals lost to Barbora Krejčíková
25	26	Ons Jabeur	2,415	10	240	240	2,415	Fourth round lost to Coco Gauff [24]
26	27	Angelique Kerber	2,320	10	10	10	2,320	First round lost to Anhelina Kalinina [Q]
27	28	Alison Riske	2,222	10+70	10	0	2,152	Withdrew due to a right knee injury
28	29	Jessica Pegula	2,219	10	10	130	2,339	Third round lost to Sofia Kenin [4]
29	30	Veronika Kudermetova	2,160	130	70	70	2,100	Second round lost to Kateřina Siniaková
30	31	Anett Kontaveit	2,145	10	10	130	2,265	Third round lost to Iga Świątek [8]
31	32	Anastasia Pavlyuchenkova	2,070	10	70	1,300	3,300	Runner-up, lost to Barbora Krejčíková
32	34	Ekaterina Alexandrova	1,940	130	130	70	1,940†	Second round lost to Barbora Krejčíková
33	35	Paula Badosa	1,870	(18)§	240	430	2,060	Quarterfinals lost to Tamara Zidanšek

†The player's 2019 points will be replaced by (or the player will continue to count) her 2020 points, which will be dropped on 11 October 2021, four months after the end of the 2021 tournament.
§The player did not qualify for the tournament in 2019. Accordingly, points from her 16th best result are deducted instead.

The following players would have been seeded, but withdrew before the tournament began.

Rank	Player	Points before	2019 Points	2020 Points	Points lost	Points after	Withdrawal reason
3	Simona Halep	6,520	430	240	190	6,330	Calf injury

The following players were awarded wildcards into the main draw.^[14]

Before the tournament

† – not included on entry list
& – withdrew from entry list

During the tournament

• Main draw
• 2021 French Open – Women's draws at the Roland Garros
• 2021 French Open – Women's draws at the International Tennis Federation