The 2020 Cary Challenger was a professional tennis tournament played on hard courts. It was the 6th edition of the tournament which was part of the 2020 ATP Challenger Tour. It took place in Cary, North Carolina, United States between 9 and 15 November 2020.

Country	Player	Rank1	Seed
BRA	Thiago Monteiro	80	1
USA	Denis Kudla	122	2
COL	Daniel Elahi Galán	131	3
IND	Prajnesh Gunneswaran	146	4
EGY	Mohamed Safwat	155	5
USA	Michael Mmoh	172	6
KAZ	Dmitry Popko	173	7
USA	Mackenzie McDonald	191	8

• ¹ Rankings are as of November 2, 2020.^[1]

The following players received wildcards into the singles main draw:

• William Blumberg
• Alexis Galarneau
• Garrett Johns

The following players received entry from the qualifying draw:

• Thomaz Bellucci
• Christian Harrison
• Kevin King
• Aleksandr Nedovyesov

• Denis Kudla def. Prajnesh Gunneswaran 3–6, 6–3, 6–0.

• Teymuraz Gabashvili / Dennis Novikov def. Luke Bambridge / Nathaniel Lammons 7–5, 4–6, [10–8].