The doubles Tournament at the 2006 NASDAQ-100 Open took place between March 20 and April 6 on the outdoor hard courts of the Tennis Center at Crandon Park in Key Biscayne, United States. Lisa Raymond and Samantha Stosur won the title, defeating Liezel Huber and Martina Navratilova in the final.

	Semifinals							Final
	1	Lisa Raymond Samantha Stosur	6	6
		Svetlana Kuznetsova Amélie Mauresmo	4	2				1	Lisa Raymond Samantha Stosur	6	7
	8	Shinobu Asagoe Katarina Srebotnik	7	1	3			7	Liezel Huber Martina Navratilova	4	5
	7	Liezel Huber Martina Navratilova	67	6	6

	First round							Second round							Quarterfinals							Semifinals
	1	L Raymond S Stosur	7	6
		A Rodionova J Wöhr	5	2				1	L Raymond S Stosur	6	6
		E Gagliardi ME Salerni	4	4					M Bartoli V Ruano Pascual	1	2
		M Bartoli V Ruano Pascual	6	6											1	L Raymond S Stosur	6	4	7
		G Dulko M Kirilenko	5	2											8	E Daniilidou A Medina Garrigues	3	6	63
		A Bondarenko K Bondarenko	7	6					A Bondarenko K Bondarenko	1	65
		E Daniilidou A Medina Garrigues	1	6	6				E Daniilidou A Medina Garrigues	6	7
	6	Z Yan J Zheng	6	0	1																	1	L Raymond S Stosur	6	6
	3	AL Grönefeld M Shaughnessy	6	5	64																		S Kuznetsova A Mauresmo	4	2
		M Krajicek C Morariu	3	7	7				M Krajicek C Morariu	3	6	2
		S Kuznetsova A Mauresmo	6	6					S Kuznetsova A Mauresmo	6	3	6
		N Dechy T Golovin	3	3												S Kuznetsova A Mauresmo	7	7
		L Domínguez Lino M Tu	3	66											5	D Hantuchová A Sugiyama	67	5
		C Gullickson B Stewart	6	7					C Gullickson B Stewart	3	6	2
		A Myskina D Safina	4	2				5	D Hantuchová A Sugiyama	6	2	6
	5	D Hantuchová A Sugiyama	6	6

	First round							Second round							Quarterfinals							Semifinals
	8	S Asagoe K Srebotnik	7	6
		J Russell A Vanc	63	1				8	S Asagoe K Srebotnik	6	7
		E Birnerová G Voskoboeva	2	4					K Clijsters C Maes	3	5
		K Clijsters C Maes	6	6											8	S Asagoe K Srebotnik	7	6
		A Ivanovic S Mirza	6	6												A Ivanovic S Mirza	5	0
		ME Camerin T Garbin	3	4					A Ivanovic S Mirza	6	6
		K Peschke F Schiavone	6	6					K Peschke F Schiavone	1	3
	4	E Likhovtseva V Zvonareva	3	0																		8	S Asagoe K Srebotnik	7	1	3
	7	L Huber M Navratilova	5	6	6																	7	L Huber M Navratilova	67	6	6
		N Petrova P Schnyder	7	2	2			7	L Huber M Navratilova	6	7
		V Dushevina S Pe'er	2	3					I Benešová B Strýcová	3	62
		I Benešová B Strýcová	6	6											7	L Huber M Navratilova	7	6
		T Li T Sun	6	6												T Li T Sun	63	4
		M Koryttseva J Kostanić	4	3					T Li T Sun	6	6
		E Loit N Pratt	7	6					E Loit N Pratt	2	4
	2	C Black R Stubbs	60	3

• Main Draw