Steffi Graf defeated Monica Seles in the final, 7–6^(8–6), 0–6, 6–3 to win the women's singles tennis title at the 1995 US Open. It was her fourth US Open title and 18th major singles title, equaling Chris Evert and Martina Navratilova's Open Era record. Graf became the only player to achieve a quadruple career Grand Slam. It was Seles's first major since her 1993 stabbing.

Arantxa Sánchez Vicario was the defending champion, but lost in the fourth round to Mary Joe Fernández.

	Quarterfinals							Semifinals							Final
	1	Steffi Graf	6	6
		Amy Frazier	2	3
								1	Steffi Graf	6	77
								9	Gabriela Sabatini	4	65
	14	Mary Joe Fernández	1	3
	9	Gabriela Sabatini	6	6
															1	Steffi Graf	78	0	6
															2	Monica Seles	66	6	3
	16	Brenda Schultz-McCarthy	6	63	2
	4	Conchita Martínez	3	77	6
								4	Conchita Martínez	2	2
								2	Monica Seles	6	6
	5	Jana Novotná	65	2
	2	Monica Seles	77	6

	First round							Second round							Third round							Fourth round
	1	S Graf	61	6	6
		A Coetzer	77	1	4			1	S Graf	6	6
	Q	R Grande	6	1	6			Q	R Grande	1	3
		A Smashnova	0	6	4										1	S Graf	6	6
		N Bradtke	3	1												N Tauziat	3	3
		N Tauziat	6	6					N Tauziat	6	6
		R Stubbs	66	6	1				P Shriver	4	3
		P Shriver	78	4	6																	1	S Graf	6	6
		G Fernández	4	6	7																		C Rubin	2	2
		I Spîrlea	6	1	5				G Fernández	77	3	6
		A Dechaume-Balleret	3	0					J Halard	62	6	4
		J Halard	6	6												G Fernández	65	1
		F Perfetti	4	1												C Rubin	77	6
		C Rubin	6	6					C Rubin	6	6
		I Demongeot	4	4				15	H Suková	1	3
	15	H Suková	6	6

	First round							Second round							Third round							Fourth round
	12	N Zvereva	6	6
		J Kandarr	4	0				12	N Zvereva	6	3	6
	Q	F Li	2	6	2				M Endo	4	6	4
		M Endo	6	3	6										12	N Zvereva	6	77
		L Neiland	6	6												A Grossman	4	65
		B Reinstadler	2	4					L Neiland	77	3	2
		A Grossman	6	6					A Grossman	64	6	6
	Q	D Randriantefy	1	3																		12	N Zvereva	4	6	3
		A Frazier	6	6																			A Frazier	6	4	6
		S Rottier	0	0					A Frazier	6	6
	WC	K Phebus	6	6				WC	K Phebus	2	1
	WC	B Rippner	3	1												A Frazier	6	78
		T Ječmenica	6	6											6	M Pierce	3	66
		N Medvedeva	3	0					T Ječmenica	3	0
		M de Swardt	4	1				6	M Pierce	6	6
	6	M Pierce	6	6

	First round							Second round							Third round							Fourth round
	3	A Sánchez Vicario	6	6
		C Cristea	1	1				3	A Sánchez Vicario	6	6
		S Stafford	63	4					J Kruger	4	3
		J Kruger	77	6											3	A Sánchez Vicario	6	6
		MJ Gaidano	3	77	6											MJ Gaidano	3	0
		B Rittner	6	62	1				MJ Gaidano	6	6
	WC	L Wild	63	0					I Gorrochategui	4	3
		I Gorrochategui	77	6																		3	A Sánchez Vicario	6	4	4
	Q	K Kschwendt	6	3	6																	14	MJ Fernández	1	6	6
		S Pitkowski	1	6	3			Q	K Kschwendt	2	6	4
		M Oremans	5	5				WC	K Adams	6	3	6
	WC	K Adams	7	7											WC	K Adams	3	1
		S Hack	6	6											14	MJ Fernández	6	6
		E Reinach	3	3					S Hack	63	3
		J Wiesner	6	4	3			14	MJ Fernández	77	6
	14	MJ Fernández	4	6	6

	First round							Second round							Third round							Fourth round
	9	G Sabatini	6	6
		A Serra Zanetti	1	1				9	G Sabatini	6	6
		E Callens	1	2				Q	N Kijimuta	2	1
	Q	N Kijimuta	6	6											9	G Sabatini	6	6
		M Strandlund	2	3												S Appelmans	1	1
	Q	M Schnell	6	6				Q	M Schnell	5	4
		E Likhovtseva	2	1					S Appelmans	7	6
		S Appelmans	6	6																		9	G Sabatini	6	6
		P Hy-Boulais	2	6	6																		M Hingis	2	4
		V Ruano Pascual	6	4	2				P Hy-Boulais	6	7
		L Ghirardi-Rubbi	1	0					C Singer	1	5
		C Singer	6	6												P Hy-Boulais	6	1	4
		M Hingis	6	6												M Hingis	4	6	6
		N Feber	2	3					M Hingis	4	6	6
		J Nejedly	4	2				8	M Maleeva	6	4	2
	8	M Maleeva	6	6

	First round							Second round							Third round							Fourth round
	7	K Date	6	2	6
		S Meier	0	6	2			7	K Date	6	1	6
		M-A Vento	6	64	2				L Raymond	2	6	4
		L Raymond	3	77	6										7	K Date	3	6	6
		F Labat	6	6												F Labat	6	1	4
		E Pampoulova	1	0					F Labat	7	65	6
		A Temesvári	6	1	4			Q	M Bollegraf	5	77	4
	Q	M Bollegraf	4	6	6																	7	K Date	5	6	2
		J Watanabe	5	6	7																	16	B Schultz-McCarthy	7	3	6
		K Nowak	7	2	5				J Watanabe	3	1
		A Gavaldón	79	77					A Gavaldón	6	6
		S Farina	67	62												A Gavaldón	2	5
		T Whitlinger-Jones	6	4	5										16	B Schultz-McCarthy	6	7
		L Lee	4	6	7				L Lee	6	3	4
		A Keller	62	6	63			16	B Schultz-McCarthy	4	6	6
	16	B Schultz-McCarthy	77	2	77

	First round							Second round							Third round							Fourth round
	10	L Davenport	6	6
		P Kamstra	2	2				10	L Davenport	1	3
		K Boogert	3	6	65				Z Garrison-Jackson	6	6
		Z Garrison-Jackson	6	1	77											Z Garrison-Jackson	6	77
		R Zrubáková	6	3	6											N Arendt	0	63
	WC	L Poruri	1	6	2				R Zrubáková	5	3
		N Miyagi	65	4					N Arendt	7	6
		N Arendt	77	6																			Z Garrison-Jackson	65	5
	Q	J Lee	77	77																		4	C Martínez	77	7
		B Schett	62	62				Q	J Lee	3	3
		N Sawamatsu	1	6	6				N Sawamatsu	6	6
		R McQuillan	6	1	3											N Sawamatsu	1	2
		R Bobková	2	1											4	C Martínez	6	6
	WC	K Po	6	6				WC	K Po	1	4
	WC	K Rinaldi-Stunkel	2	2				4	C Martínez	6	6
	4	C Martínez	6	6

	First round							Second round							Third round							Fourth round
	5	J Novotná	6	6
		S Cecchini	2	0				5	J Novotná	6	6
		Å Carlsson	6	6					Å Carlsson	1	2
		S Cacic	4	2											5	J Novotná	6	7
		V Martinek	3	0												S Testud	4	5
		D Monami	6	6					D Monami	1	4
		S Testud	7	6					S Testud	6	6
		P Suárez	5	4																		5	J Novotná	6	6
		L Courtois	4	60																			K Studeníková	4	3
		K Studeníková	6	77					K Studeníková	6	6
		T Ignatieva	0	2					A Sugiyama	3	3
		A Sugiyama	6	6												K Studeníková	4	6	6
		N Baudone	6	6												N Baudone	6	3	2
		K Nagatsuka	2	4					N Baudone	6	6
		B Paulus	6	6					B Paulus	4	1
	13	I Majoli	4	4

	First round							Second round							Third round							Fourth round
	11	A Huber	6	6
		Y Basuki	2	3				11	A Huber	6	7
		K Habšudová	6	3	3			WC	A Miller	0	5
	WC	A Miller	4	6	6										11	A Huber	2	6	6
		E Makarova	6	7												E Makarova	6	3	1
		M McGrath	1	5					E Makarova	4	6	77
		L Richterová	3	77	2				L McNeil	6	2	63
		L McNeil	6	62	6																	11	A Huber	1	4
		S-h Park	5	66																		2	M Seles	6	6
		M Werdel-Witmeyer	7	78					M Werdel-Witmeyer	2	77	3
		M Tang	5	5					Y Kamio	6	60	6
		Y Kamio	7	7												Y Kamio	1	1
		P Schwarz-Ritter	66	2											2	M Seles	6	6
		E deLone	78	6					E deLone	2	1
		R Dragomir	3	1				2	M Seles	6	6
	2	M Seles	6	6

• 1995 US Open – Women's draws and results at the International Tennis Federation