William and Mary often refers to:

• The joint reign of William III of England (II of Scotland) and Mary II of England (and Scotland)
• William and Mary style, a furniture design common from 1700 to 1725 named for the couple

William and Mary may also refer to:

• College of William & Mary in Virginia, or associated organizations:
  • William & Mary Law School
  • William & Mary Pep Band
  • William & Mary Police
  • William & Mary Tribe athletic teams representing the College
  • William and Mary Quarterly, a history journal

• "William and Mary" (short story), published in 1959 by Roald Dahl
• William and Mary (TV series), a British romantic comedy-drama

• HMS Pitt (1805), a schooner known as William and Mary before Royal Navy service
• HMY William & Mary (1694)
• HMY William & Mary (1807), see List of royal yachts of the United Kingdom
• SS William and Mary Victory

• Fort William and Mary, defended by soldiers of New Castle, New Hampshire

• All pages with titles containing William and Mary
• Victoria and Albert (disambiguation)