William Combe (1742–1823) was a British writer.
William Combe may also refer to:
- William Combe (15th century MP), MP for Chichester
- William Combe (died 1610) (1551–1610), MP for Droitwich, Warwick and Warwickshire
- William Combe (died 1667) (1586–1667), MP for Warwickshire
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