In enzymology, an omega-hydroxydecanoate dehydrogenase (EC 1.1.1.66) is an enzyme that catalyzes the chemical reaction

10-hydroxydecanoate + NAD⁺ ⇌ 10-oxodecanoate + NADH + H⁺

Thus, the two substrates of this enzyme are 10-hydroxydecanoate and NAD⁺, whereas its 3 products are 10-oxodecanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 10-hydroxydecanoate:NAD⁺ 10-oxidoreductase.

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• Mitz MA; Henrikson RL (1961). "Omega hydroxy fatty acid dehydrogenase". Biochim. Biophys. Acta. 46: 45–50. doi:10.1016/0006-3002(61)90644-8. PMID 13771448.